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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3017 Species: Rattus norvegicus RGD Object: Gene Symbol: Lpl Name: lipoprotein lipase

Acc ID: CHEBI:6682 Term: mangiferin Definition: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position. CasRN: 4773-96-0 Chemical ID: MESH:C013592

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:70836	6480464	CTD	L 663536 inhibits the reaction [mangiferin results in increased activity of LPL protein] L 663536 inhibits the reaction [mangiferin results in increased expression of LPL mRNA]	PMID:15975614
increases expression	ISO	RGD:70836	6480464	CTD	mangiferin results in increased expression of LPL mRNA	PMID:15975614
increases activity	ISO	RGD:70836	6480464	CTD	mangiferin results in increased activity of LPL protein	PMID:15975614