GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Lepr | decreases expression | EXP | | 6480464 | CTD | Ozone results in decreased expression of LEPR mRNA | PMID:26667333 | Lepr | increases response to substance | ISO | Lepr (Mus musculus) | 6480464 | CTD | LEPR gene mutant form results in increased susceptibility to Ozone | PMID:16373670 | Lepr | multiple interactions | ISO | Lepr (Mus musculus) | 6480464 | CTD | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of LEPR mRNA; [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of LEPR mRNA; LEPR gene mutant form promotes the reaction [Ozone results in increased expression of CCL11 protein]; LEPR gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]; LEPR gene mutant form promotes the reaction [Ozone results in increased expression of CXCL2 protein]; LEPR gene mutant form promotes the reaction [Ozone results in increased expression of IL6 protein] | PMID:16373670 PMID:27106289 PMID:34911549 | Lepr | multiple interactions | ISO | LEPR (Homo sapiens) | 6480464 | CTD | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of and results in increased oxidation of LEPR mRNA; [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased expression of LEPR mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of and results in increased oxidation of LEPR mRNA; [Volatile Organic Compounds co-treated with Ozone] results in increased expression of and results in increased oxidation of LEPR mRNA | PMID:32699268 PMID:32845096 | | ||||||||||||||||||||||
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