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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: CHEBI:15355
Term: acetylcholine
Definition: Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Chemical ID: MESH:D000109
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Leprdecreases response to substanceISOLepr (Mus musculus)6480464CTDLEPR gene mutant form results in decreased susceptibility to AcetylcholinePMID:19478208
Leprmultiple interactionsISOLepr (Mus musculus)6480464CTDacetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; resveratrol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; tempol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; TNF gene mutant form affects the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]PMID:19478208
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