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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldha
Name: lactate dehydrogenase A
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldhamultiple interactionsEXP 6480464CTD[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]; Quercetin inhibits the reaction [difenoconazole results in increased activity of LDHA protein]; Quercetin inhibits the reaction [Doxorubicin results in increased activity of LDHA protein]; Quercetin inhibits the reaction [Rotenone results in increased activity of LDHA protein]; YWHAG protein promotes the reaction [Quercetin inhibits the reaction [Doxorubicin results in increased activity of LDHA protein]]PMID:21322096 PMID:28679351 PMID:30636491 PMID:35337893
Ldhadecreases expressionISOLdha (Mus musculus)6480464CTDQuercetin results in decreased expression of LDHA mRNA; Quercetin results in decreased expression of LDHA proteinPMID:25658812
Ldhadecreases expressionISOLDHA (Homo sapiens)6480464CTDQuercetin results in decreased expression of LDHA proteinPMID:35945655
Ldhaincreases expressionISOLDHA (Homo sapiens)6480464CTDQuercetin results in increased expression of LDHA proteinPMID:19207037
Ldhamultiple interactionsISOLDHA (Homo sapiens)6480464CTDG3BP1 protein inhibits the reaction [Quercetin results in decreased expression of LDHA protein]PMID:35945655
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