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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jund
Name: JunD proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jundaffects expressionISOJUND (Homo sapiens)6480464CTDEstradiol affects the expression of JUND mRNAPMID:14699072
Jundincreases expressionISOJund (Mus musculus)6480464CTDEstradiol results in increased expression of JUND mRNAPMID:25210133
Jundmultiple interactionsISOJUND (Homo sapiens)6480464CTDEstradiol promotes the reaction [ESR1 protein binds to JUND promoter]PMID:23019147
Jundmultiple interactionsISOJund (Mus musculus)6480464CTD[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of JUND mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of JUND mRNAPMID:11509743
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