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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2944
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Junb
Name: JunB proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junbdecreases expressionISOJUNB (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of JUNB mRNAPMID:12016162 PMID:34032870
Junbdecreases expressionISOJunb (Mus musculus)6480464CTDsodium arsenite results in decreased expression of JUNB mRNAPMID:33933676
Junbincreases activityISOJUNB (Homo sapiens)6480464CTDsodium arsenite results in increased activity of JUNB proteinPMID:12220541
Junbincreases expressionISOJUNB (Homo sapiens)6480464CTDsodium arsenite results in increased expression of JUNB mRNAPMID:12634122
Junbincreases expressionISOJunb (Mus musculus)6480464CTDsodium arsenite results in increased expression of JUNB mRNAPMID:11353140 PMID:36209798
Junbmultiple interactionsISOJUNB (Homo sapiens)6480464CTD[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of JUNB mRNA; sodium arsenite affects the reaction [JUNB protein binds to IVL promoter]; sodium arsenite results in increased phosphorylation of and results in increased activity of JUNB proteinPMID:12475910 PMID:12634122 PMID:20006635
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