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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rdecreases expressionISOIgf1r (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of IGF1R mRNAPMID:15034205 PMID:21803694
Igf1rdecreases expressionISOIGF1R (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of IGF1R mRNAPMID:20106945 PMID:21632981 PMID:22316170 PMID:26238291
Igf1rdecreases methylationISOIgf1r (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of IGF1R intronPMID:27901495
Igf1rincreases phosphorylationISOIGF1R (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased phosphorylation of IGF1R proteinPMID:9683191
Igf1rmultiple interactionsISOIgf1r (Mus musculus)6480464CTDAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of IGF1R mRNA]PMID:15034205
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