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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868 Species: Rattus norvegicus RGD Object: Gene Symbol: Igf1 Name: insulin-like growth factor 1

Acc ID: CHEBI:45783 Term: imatinib Definition: A benzamide obtained by formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary aromatic amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine. Used (as its mesylate salt) for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours. CasRN: 152459-95-5 Chemical ID: MESH:C097613

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:70506	6480464	CTD	imatinib promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]] imatinib promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of MTOR protein]]	PMID:16740780