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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1affects activityEXP 6480464CTDCyclosporine affects the activity of IGF1 proteinPMID:11548882
Igf1multiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [IGF1 protein results in increased expression of NPPA mRNA]PMID:11548882
Igf1affects expressionISOIGF1 (Homo sapiens)6480464CTDCyclosporine affects the expression of IGF1 mRNAPMID:33631201
Igf1decreases expressionISOIgf1 (Mus musculus)6480464CTDCyclosporine results in decreased expression of IGF1 mRNAPMID:19770486
Igf1decreases expressionISOIGF1 (Homo sapiens)6480464CTDCyclosporine results in decreased expression of IGF1 mRNAPMID:20106945 PMID:27989131
Igf1increases secretionISOIGF1 (Homo sapiens)6480464CTDCyclosporine results in increased secretion of IGF1 proteinPMID:16882103
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTDCyclosporine inhibits the reaction [IGF1 protein results in increased activity of HIF1A protein]; Cyclosporine inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]PMID:16682453
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