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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of IGF1 mRNA; Arsenic Trioxide results in decreased expression of IGF1 proteinPMID:31258454 PMID:34037972
Igf1multiple interactionsEXP 6480464CTDPhloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of IGF1 mRNA]PMID:34037972
Igf1affects response to substanceISOIGF1 (Homo sapiens)6480464CTDIGF1 mRNA affects the susceptibility to Arsenic TrioxidePMID:23911876
Igf1decreases expressionISOIGF1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of IGF1 mRNAPMID:20458559
Igf1increases expressionISOIGF1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of IGF1 mRNAPMID:18414637 PMID:23911876
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [IGF1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Arsenic Trioxide inhibits the reaction [IGF1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]PMID:23041229
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