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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1decreases expressionEXP 6480464CTDZinc deficiency results in decreased expression of IGF1 mRNA; Zinc deficiency results in decreased expression of IGF1 proteinPMID:10985758 PMID:20128680 PMID:20404036 PMID:21893222 PMID:7722689
Igf1increases expressionEXP 6480464CTDZinc deficiency results in increased expression of IGF1 mRNA; Zinc deficiency results in increased expression of IGF1 proteinPMID:12672911 PMID:15990634 PMID:20660286
Igf1increases expressionISOIGF1 (Homo sapiens)6480464CTDZinc deficiency results in increased expression of IGF1 mRNAPMID:18356318
Igf1increases importISOIgf1 (Mus musculus)6480464CTDIGF1 protein results in increased import of ZincPMID:16443356
Igf1multiple interactionsISOIgf1 (Mus musculus)6480464CTD[Zinc binds to calcium silicate] which results in increased expression of IGF1 mRNAPMID:23483914
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTDZinc promotes the reaction [IGF1 protein binds to IGF1R protein]PMID:9648927
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