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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1decreases expressionEXP 6480464CTDEstradiol results in decreased expression of IGF1 proteinPMID:11408345
Igf1increases abundanceEXP 6480464CTDIGF1 protein results in increased abundance of EstradiolPMID:21239528
Igf1increases expressionEXP 6480464CTDEstradiol results in increased expression of IGF1 mRNAPMID:15979666 PMID:16414171 PMID:20381596 PMID:32145629
Igf1multiple interactionsEXP 6480464CTD2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]; BMP15 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]; BMP2 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]; BMP4 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]; BMP6 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]; BMP7 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]; Estradiol inhibits the reaction [Triiodothyronine results in increased expression of IGF1 mRNA]; Estradiol inhibits the reaction [Triiodothyronine results in increased secretion of IGF1 protein]; IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]PMID:16414171 PMID:22067323 PMID:7684602
Igf1affects expressionISOIGF1 (Homo sapiens)6480464CTDEstradiol affects the expression of IGF1 mRNAPMID:21826169
Igf1decreases expressionISOIgf1 (Mus musculus)6480464CTDEstradiol results in decreased expression of IGF1 mRNAPMID:11509743 PMID:22467019
Igf1decreases expressionISOIGF1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of IGF1 mRNA; Estradiol results in decreased expression of IGF1 proteinPMID:10843175 PMID:15855258 PMID:17484513 PMID:17872375
Igf1increases abundanceISOIGF1 (Homo sapiens)6480464CTDIGF1 protein results in increased abundance of EstradiolPMID:19081562 PMID:22798350 PMID:23315983
Igf1increases expressionISOIgf1 (Mus musculus)6480464CTDEstradiol results in increased expression of IGF1 mRNAPMID:14664709 PMID:19341330 PMID:19920132 PMID:25210133 PMID:8390853
Igf1increases expressionISOIGF1 (Homo sapiens)6480464CTDEstradiol results in increased expression of IGF1 mRNA; Estradiol results in increased expression of IGF1 proteinPMID:15762036 PMID:15969240 PMID:17872375 PMID:21795739 PMID:23094148 PMID:27271280 PMID:31923581
Igf1increases secretionISOIGF1 (Homo sapiens)6480464CTDEstradiol results in increased secretion of IGF1 proteinPMID:15809018
Igf1multiple interactionsISOIgf1 (Mus musculus)6480464CTD[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of IGF1 mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of IGF1 mRNA; [Estradiol co-treated with Progesterone] promotes the reaction [Cuprizone results in increased expression of IGF1 mRNA]; Dronabinol affects the reaction [Estradiol results in increased expression of IGF1 mRNA]; ESR1 protein mutant form inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]; Estradiol affects the reaction [CYP19A1 affects the expression of IGF1 mRNA]; Estradiol promotes the reaction [ESR1 protein binds to IGF1 promoter]; Estradiol promotes the reaction [Progesterone results in increased expression of IGF1 mRNA]; Progesterone promotes the reaction [Estradiol results in increased expression of IGF1 mRNA]PMID:11509743 PMID:11985600 PMID:19031445 PMID:19920132 PMID:8390853
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; [Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein; [IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein; [IGF1 protein co-treated with Estradiol] results in increased phosphorylation of ESR1 protein; [IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein; [IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein; [IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein; [IGF1 protein co-treated with FSHB protein] results in increased abundance of Estradiol; [Tetrachlorodibenzodioxin co-treated with Estradiol] inhibits the reaction [IGF1 protein results in increased uptake of Thymidine]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; ADIPOQ protein promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Bucladesine promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Estradiol inhibits the reaction [NCOR1 protein binds to IGF1 promoter]; Estradiol promotes the reaction [CREBBP protein binds to IGF1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to IGF1 promoter]; Estradiol promotes the reaction [ESR2 protein binds to IGF1 promoter]; Estradiol promotes the reaction [NCOA1 protein binds to IGF1 promoter]; Estradiol promotes the reaction [NCOA2 protein binds to IGF1 promoter]; Estradiol promotes the reaction [NCOA3 protein binds to IGF1 promoter]; Estradiol results in increased expression of and affects the localization of IGF1 protein; FGF9 protein inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased abundance of Estradiol]; FGF9 protein inhibits the reaction [Bucladesine promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]; FGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]; FGF9 protein inhibits the reaction [IGF1 protein results in increased abundance of Estradiol]; Mifepristone inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]; NAMPT protein promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Tamoxifen inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased secretion of IGF1 protein]PMID:1332906 PMID:15809018 PMID:17458902 PMID:17872375 PMID:19081562 PMID:22798350 PMID:23094148 PMID:23315983 PMID:31923581
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