Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]; BMP15 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]; BMP2 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]; BMP4 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]; BMP6 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]; BMP7 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]; Estradiol inhibits the reaction [Triiodothyronine results in increased expression of IGF1 mRNA]; Estradiol inhibits the reaction [Triiodothyronine results in increased secretion of IGF1 protein]; IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]
[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of IGF1 mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of IGF1 mRNA; [Estradiol co-treated with Progesterone] promotes the reaction [Cuprizone results in increased expression of IGF1 mRNA]; Dronabinol affects the reaction [Estradiol results in increased expression of IGF1 mRNA]; ESR1 protein mutant form inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]; Estradiol affects the reaction [CYP19A1 affects the expression of IGF1 mRNA]; Estradiol promotes the reaction [ESR1 protein binds to IGF1 promoter]; Estradiol promotes the reaction [Progesterone results in increased expression of IGF1 mRNA]; Progesterone promotes the reaction [Estradiol results in increased expression of IGF1 mRNA]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; 3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; [Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein; [IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein; [IGF1 protein co-treated with Estradiol] results in increased phosphorylation of ESR1 protein; [IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein; [IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein; [IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein; [IGF1 protein co-treated with FSHB protein] results in increased abundance of Estradiol; [Tetrachlorodibenzodioxin co-treated with Estradiol] inhibits the reaction [IGF1 protein results in increased uptake of Thymidine]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; ADIPOQ protein promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Bucladesine promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Estradiol inhibits the reaction [NCOR1 protein binds to IGF1 promoter]; Estradiol promotes the reaction [CREBBP protein binds to IGF1 promoter]; Estradiol promotes the reaction [ESR1 protein binds to IGF1 promoter]; Estradiol promotes the reaction [ESR2 protein binds to IGF1 promoter]; Estradiol promotes the reaction [NCOA1 protein binds to IGF1 promoter]; Estradiol promotes the reaction [NCOA2 protein binds to IGF1 promoter]; Estradiol promotes the reaction [NCOA3 protein binds to IGF1 promoter]; Estradiol results in increased expression of and affects the localization of IGF1 protein; FGF9 protein inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased abundance of Estradiol]; FGF9 protein inhibits the reaction [Bucladesine promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]; FGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]; FGF9 protein inhibits the reaction [IGF1 protein results in increased abundance of Estradiol]; Mifepristone inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]; NAMPT protein promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Tamoxifen inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased secretion of IGF1 protein]