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GENE - TERM ANNOTATION REPORT

RGD ID: 2862
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Idh1
Name: isocitrate dehydrogenase (NADP(+)) 1
Acc ID: DOID:3068
Term: glioblastoma
Definition: A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes. (DO)
Definition Source(s): http://cancergenome.nih.gov/cancersselected/glioblastomamultiforme "DO" "DO", http://en.wikipedia.org/wiki/Glioblastoma_multiforme "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/20129251 "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/23029035 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Idh1disease_progressionISOIDH1 (Homo sapiens)11074562RGDDNA:mutation:cds:p.R132(human) 
Idh1onsetISOIDH1 (Homo sapiens)11522732RGDDNA:mutation:cds:p.R132H(human) 
Idh1 ISOIDH1 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Glioblastoma | ClinVar Annotator: match by term: Glioblastoma, somaticPMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 PMID:21352804 PMID:21446021 PMID:22160010 PMID:22397365 PMID:22417203 PMID:22898539 PMID:23558169 PMID:24606448 PMID:25043048 PMID:25157968 PMID:25741868 PMID:26619011 PMID:27993330 PMID:30231226 PMID:36201590
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