GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Iapp | affects binding | EXP | | 6480464 | CTD | Copper binds to IAPP protein | PMID:23793354 | Iapp | multiple interactions | EXP | | 6480464 | CTD | Copper promotes the reaction [IAPP protein results in increased chemical synthesis of Hydrogen Peroxide]; IAPP protein promotes the reaction [[Copper co-treated with Ascorbic Acid] results in increased abundance of Hydrogen Peroxide]; IAPP protein promotes the reaction [[Copper co-treated with Ascorbic Acid] results in increased abundance of Hydroxyl Radical] | PMID:23793354 | Iapp | affects binding | ISO | IAPP (Homo sapiens) | 6480464 | CTD | Copper binds to IAPP protein | PMID:23793354 | Iapp | multiple interactions | ISO | Iapp (Mus musculus) | 6480464 | CTD | Copper affects the reaction [IDE protein affects the degradation of IAPP protein] | PMID:24719342 | Iapp | multiple interactions | ISO | IAPP (Homo sapiens) | 6480464 | CTD | Copper affects the reaction [IDE protein affects the degradation of IAPP protein]; Copper inhibits the reaction [IAPP protein binds to IAPP protein]; Copper inhibits the reaction [IAPP protein results in increased cleavage of CASP3 protein]; Copper inhibits the reaction [IAPP protein results in increased expression of JUN protein modified form]; Copper inhibits the reaction [IAPP protein results in increased phosphorylation of MAPK8 protein]; Copper inhibits the reaction [IAPP protein results in increased phosphorylation of MAPK9 protein]; Copper promotes the reaction [IAPP protein results in increased chemical synthesis of Hydrogen Peroxide]; IAPP protein inhibits the reaction [[Copper co-treated with Glutathione] results in increased abundance of Hydrogen Peroxide] | PMID:23793354 PMID:24719342 | | ||||||||||||||||||||||
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