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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2854
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Iapp
Name: islet amyloid polypeptide
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Iappincreases expressionEXP 6480464CTDGlucose results in increased expression of IAPP mRNAPMID:9142872
Iappmultiple interactionsEXP 6480464CTDDiazoxide inhibits the reaction [Glucose results in increased expression of IAPP mRNA]; Mannoheptulose inhibits the reaction [Glucose results in increased expression of IAPP mRNA]; Verapamil inhibits the reaction [Glucose results in increased expression of IAPP mRNA]PMID:9142872
Iappmultiple interactionsISOIAPP (Homo sapiens)6480464CTDIAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]; rosiglitazone inhibits the reaction [IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]]PMID:16204373
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