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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2840 Species: Rattus norvegicus RGD Object: Gene Symbol: Hspa1b Name: heat shock protein 1B

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	ISO	RGD:736399	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of HSPA1B mRNA	PMID:18691609
multiple interactions	ISO	RGD:736399	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA	PMID:15340226
increases expression	ISO	RGD:736399	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of HSPA1B mRNA	PMID:15340226 PMID:17035482
increases expression	ISO	RGD:736399	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of HSPA1B protein	PMID:15340226
decreases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of HSPA1B protein	PMID:16548065
increases expression	ISO	RGD:736399	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of HSPA1B mRNA	PMID:17035482 PMID:15340226
multiple interactions	ISO	RGD:736399	6480464	CTD	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HSPA1B promoter]	PMID:19654925
decreases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of HSPA1B mRNA	PMID:21215274
increases expression	ISO	RGD:736399	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of HSPA1B mRNA	PMID:15034205 PMID:15340226 PMID:17035482
multiple interactions	ISO	RGD:736399	6480464	CTD	AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of HSPA1B mRNA]	PMID:15034205