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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2810
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hnf4a
Name: hepatocyte nuclear factor 4, alpha
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hnf4adecreases activityISOHnf4a (Mus musculus)6480464CTDEthanol results in decreased activity of HNF4A proteinPMID:19637192
Hnf4adecreases expressionISOHnf4a (Mus musculus)6480464CTDEthanol results in decreased expression of HNF4 proteinPMID:25455889
Hnf4amultiple interactionsISOHnf4a (Mus musculus)6480464CTD[Ethanol co-treated with Zinc] results in increased expression of HNF4A mRNA; Berberine inhibits the reaction [Ethanol results in decreased expression of HNF4 protein]; Zinc inhibits the reaction [Ethanol results in decreased activity of HNF4A protein]PMID:19637192 PMID:25455889
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