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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:8058
Term: phencyclidine
Definition: A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.
Chemical ID: MESH:D010622
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDPhencyclidine results in increased expression of HMOX1 mRNA; Phencyclidine results in increased expression of HMOX1 proteinPMID:9875361
Hmox1multiple interactionsEXP 6480464CTD1,3-dimethylthiourea inhibits the reaction [Phencyclidine results in increased expression of HMOX1 protein]PMID:9875361
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