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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:6413
Term: letrozole
Definition: A triazole that has formula C17H11N5.
Chemical ID: MESH:C067431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1decreases expressionEXP 6480464CTDletrozole results in decreased expression of HMOX1 proteinPMID:28619389
Hmox1multiple interactionsEXP 6480464CTDindole-3-carbinol inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]]; Linagliptin inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]]PMID:28619389
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