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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDChlorpyrifos results in increased expression of HMOX1 mRNA; Chlorpyrifos results in increased expression of HMOX1 proteinPMID:20691718 PMID:22714038
Hmox1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of HMOX1 protein]PMID:22714038
Hmox1affects expressionISOHMOX1 (Homo sapiens)6480464CTDChlorpyrifos affects the expression of HMOX1 proteinPMID:24793810 PMID:33930485
Hmox1decreases expressionISOHmox1 (Mus musculus)6480464CTDChlorpyrifos results in decreased expression of HMOX1 mRNAPMID:36152060
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDChlorpyrifos results in increased expression of HMOX1 mRNAPMID:34289071
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of HMOX1 mRNAPMID:23850137
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTDChlorpyrifos inhibits the reaction [taxifolin results in decreased expression of HMOX1 protein]; Ginsenosides inhibits the reaction [Chlorpyrifos results in decreased expression of HMOX1 mRNA]PMID:31152760 PMID:36152060
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDAcetylcysteine affects the reaction [Chlorpyrifos affects the expression of HMOX1 protein]; Rosiglitazone affects the reaction [Chlorpyrifos affects the expression of HMOX1 protein]PMID:24793810 PMID:33930485
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