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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:28619
Term: acrylamide
Definition: A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia.
Chemical ID: MESH:D020106
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDAcrylamide results in increased expression of HMOX1 mRNA; Acrylamide results in increased expression of HMOX1 proteinPMID:28606764 PMID:29426002
Hmox1multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of HMOX1 mRNA]; U 0126 inhibits the reaction [Acrylamide results in increased expression of HMOX1 mRNA]PMID:29426002
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDAcrylamide results in increased expression of HMOX1 mRNA; Acrylamide results in increased expression of HMOX1 proteinPMID:27836571 PMID:28526328 PMID:33872730
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDAcrylamide results in increased expression of HMOX1 mRNAPMID:32763439
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTD[NLRP3 gene mutant form affects the susceptibility to Acrylamide] which results in increased expression of HMOX1 proteinPMID:32014472
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