GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gstm1 | affects methylation | ISO | GSTM1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of GSTM1 exon; Benzo(a)pyrene affects the methylation of GSTM1 promoter | PMID:27901495 | Gstm1 | affects response to substance | ISO | GSTM1 (Homo sapiens) | 6480464 | CTD | GSTM1 gene polymorphism affects the susceptibility to Benzo(a)pyrene | PMID:15471894 | Gstm1 | decreases expression | ISO | GSTM1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of GSTM1 mRNA | PMID:17253728 PMID:32234424 | Gstm1 | decreases response to substance | ISO | GSTM1 (Homo sapiens) | 6480464 | CTD | GSTM1 protein results in decreased susceptibility to Benzo(a)pyrene metabolite | PMID:17525473 | Gstm1 | increases activity | ISO | Gstm1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased activity of GSTM1 protein | PMID:30938511 | Gstm1 | increases expression | ISO | Gstm1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of GSTM1 mRNA | PMID:15034205 PMID:19770486 PMID:20127859 PMID:21569818 PMID:22228805 PMID:32417428 | Gstm1 | increases response to substance | ISO | GSTM1 (Homo sapiens) | 6480464 | CTD | GSTM1 gene polymorphism results in increased susceptibility to Benzo(a)pyrene | PMID:7728947 | Gstm1 | multiple interactions | ISO | Gstm1 (Mus musculus) | 6480464 | CTD | [lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GSTM1 mRNA; AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of GSTM1 mRNA] | PMID:15034205 PMID:28987381 | Gstm1 | multiple interactions | ISO | GSTM1 (Homo sapiens) | 6480464 | CTD | [Docosahexaenoic Acids co-treated with Benzo(a)pyrene] results in decreased expression of GSTM1 protein; GSTM1 protein affects the metabolism of [Benzo(a)pyrene co-treated with Glutathione]; GSTM1 protein inhibits the reaction [CYP1A1 protein promotes the reaction [Benzo(a)pyrene results in increased mutagenesis of HPRT1 gene]]; GSTM1 protein inhibits the reaction [CYP1A1 protein results in increased susceptibility to Benzo(a)pyrene]; GSTM1 protein polymorphism affects the metabolism of and affects the activity of Benzo(a)pyrene | PMID:15298956 PMID:17525473 PMID:25956473 PMID:9403173 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |