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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2703
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Glp1r
Name: glucagon-like peptide 1 receptor
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Glp1rmultiple interactionsEXP 6480464CTD[GCG protein modified form binds to and results in increased activity of GLP1R protein] promotes the reaction [Glucose results in increased secretion of INS1 protein]; [Glucose co-treated with Oleic Acid] results in decreased expression of GLP1R protein; Exenatide inhibits the reaction [[Glucose co-treated with Oleic Acid] results in decreased expression of GLP1R protein]PMID:18669601 PMID:22925809
Glp1rmultiple interactionsISOGlp1r (Mus musculus)6480464CTD[GCG protein modified form binds to and results in increased activity of GLP1R protein] promotes the reaction [Glucose results in increased secretion of INS1 protein]PMID:18669601
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