Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2702
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Glo1
Name: glyoxalase 1
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Glo1decreases activityEXP 6480464CTDtroglitazone results in decreased activity of GLO1 mRNA; troglitazone results in decreased activity of GLO1 proteinPMID:11719831
Glo1decreases activityISOGLO1 (Homo sapiens)6480464CTDtroglitazone results in decreased activity of GLO1 mRNA; troglitazone results in decreased activity of GLO1 proteinPMID:11719831 PMID:12572858
Glo1decreases expressionISOGLO1 (Homo sapiens)6480464CTDtroglitazone results in decreased expression of GLO1 mRNAPMID:12572858
Glo1multiple interactionsISOGLO1 (Homo sapiens)6480464CTD[troglitazone results in decreased expression of GLO1 mRNA] which results in increased susceptibility to Doxorubicin; troglitazone inhibits the reaction [GLO1 mRNA results in decreased susceptibility to Doxorubicin]PMID:16085563
Go Back to source page   Continue to Ontology report