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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2702
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Glo1
Name: glyoxalase 1
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Glo1decreases expressionEXP 6480464CTDGlucose results in decreased expression of GLO1 mRNAPMID:32643284
Glo1multiple interactionsEXP 6480464CTDmorroniside inhibits the reaction [Glucose results in decreased expression of GLO1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of GLO1 protein]PMID:32643284
Glo1decreases expressionISOGLO1 (Homo sapiens)6480464CTDGlucose results in decreased expression of GLO1 proteinPMID:19833897
Glo1multiple interactionsISOGLO1 (Homo sapiens)6480464CTDGLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to HMGB1 promoter]]; GLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to S100A12 promoter]]; GLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to S100A8 promoter]]; GLO1 inhibits the reaction [Glucose promotes the reaction [RELA protein binds to AGER promoter]]; GLO1 inhibits the reaction [Glucose results in decreased expression of GLO1 protein]; GLO1 inhibits the reaction [Glucose results in increased expression of AGER mRNA]; GLO1 inhibits the reaction [Glucose results in increased expression of AGER protein]; GLO1 inhibits the reaction [Glucose results in increased expression of and results in increased secretion of HMGB1 protein]; GLO1 inhibits the reaction [Glucose results in increased expression of HMGB1 mRNA]; GLO1 inhibits the reaction [Glucose results in increased expression of S100A12 mRNA]; GLO1 inhibits the reaction [Glucose results in increased expression of S100A8 mRNA]; GLO1 inhibits the reaction [Glucose results in increased expression of S100A8 protein]; SOD2 inhibits the reaction [Glucose results in decreased expression of GLO1 protein]; UCP1 inhibits the reaction [Glucose results in decreased expression of GLO1 protein]PMID:19833897
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