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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gapdhdecreases expressionISOGapdh (Mus musculus)6480464CTD1-Methyl-4-phenylpyridinium results in decreased expression of GAPDH mRNAPMID:22776087
Gapdhincreases expressionISOGAPDH (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of GAPDH mRNA; 1-Methyl-4-phenylpyridinium results in increased expression of GAPDH proteinPMID:14724376 PMID:24675778
Gapdhmultiple interactionsISOGAPDH (Homo sapiens)6480464CTDSelegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of GAPDH mRNA]PMID:14724376
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