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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gapdhmultiple interactionsEXP 6480464CTD[chloroacetaldehyde results in decreased activity of GAPDH protein] which results in decreased chemical synthesis of Glucose; UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]; UCP1 protein inhibits the reaction [Glucose results in decreased activity of and results in increased ADP-ribosylation of GAPDH protein]PMID:11050244 PMID:14523042 PMID:19733226
Gapdhincreases ADP-ribosylationISOGapdh (Mus musculus)6480464CTDGlucose results in increased ADP-ribosylation of GAPDH proteinPMID:14523042
Gapdhincreases expressionISOGAPDH (Homo sapiens)6480464CTDGlucose results in increased expression of GAPDH mRNAPMID:7826318
Gapdhmultiple interactionsISOGapdh (Mus musculus)6480464CTD[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of GAPDH mRNA; PARP1 protein affects the reaction [Glucose results in increased ADP-ribosylation of GAPDH protein]PMID:14523042 PMID:37567420
Gapdhmultiple interactionsISOGAPDH (Homo sapiens)6480464CTDSOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]; SOD2 protein inhibits the reaction [Glucose results in decreased activity of and results in increased ADP-ribosylation of GAPDH protein]PMID:11050244 PMID:14523042
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