Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: G6pd
Name: glucose-6-phosphate dehydrogenase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
G6pdaffects methylationISOG6PD (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of G6PD 5' UTRPMID:27901495
G6pddecreases expressionISOG6pdx (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of G6PDX mRNAPMID:22228805
G6pdincreases expressionISOG6pdx (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of G6PDX mRNAPMID:14625279 PMID:19770486 PMID:21569818 PMID:21715664 PMID:25908611
G6pdmultiple interactionsISOG6pdx (Mus musculus)6480464CTD[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of G6PDX mRNA]; AHR protein affects the reaction [Benzo(a)pyrene affects the expression of G6PDX mRNA]PMID:14625279 PMID:22228805
G6pdmultiple interactionsISOG6PD (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of G6PD mRNA; [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of G6PD mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of G6PD mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of G6PD mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of G6PD mRNA; [Soot co-treated with Benzo(a)pyrene] results in increased expression of G6PD proteinPMID:17690111 PMID:24464499
Go Back to source page   Continue to Ontology report