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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: G6pd
Name: glucose-6-phosphate dehydrogenase
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
G6pdmultiple interactionsEXP 6480464CTDQuercetin analog inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein]; Quercetin inhibits the reaction [Cadmium results in decreased expression of G6PD protein]PMID:19615871 PMID:20371363
G6pdincreases expressionISOG6PD (Homo sapiens)6480464CTDQuercetin results in increased expression of G6PD mRNAPMID:21632981
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