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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2621
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Flt1
Name: Fms related receptor tyrosine kinase 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Flt1increases expressionEXP 6480464CTDStreptozocin results in increased expression of FLT1 mRNAPMID:20821229
Flt1multiple interactionsEXP 6480464CTDSimvastatin inhibits the reaction [Streptozocin results in increased expression of FLT1 mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of FLT1 protein]; Streptozocin results in increased phosphorylation of and results in increased expression of FLT1 proteinPMID:20821229
Flt1increases expressionISOFlt1 (Mus musculus)6480464CTDStreptozocin results in increased expression of FLT1 mRNAPMID:26073000
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