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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxg1
Name: forkhead box G1
Acc ID: CHEBI:53509
Term: erlotinib hydrochloride
Definition: The hydrochloride salt of erlotinib.
Chemical ID: MESH:D000069347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxg1decreases expressionISOFOXG1 (Homo sapiens)6480464CTDErlotinib Hydrochloride results in decreased expression of FOXG1 proteinPMID:26455392
Foxg1multiple interactionsISOFOXG1 (Homo sapiens)6480464CTDErlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 protein]PMID:26455392
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