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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2561
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:75832
Term: iron(2+) sulfate (anhydrous)
Definition: A compound of iron and sulfate in which the ratio of iron(2+) to sulfate ions is 1:1. Various hydrates occur naturally - most commonly the heptahydrate, which loses water to form the tetrahydrate at 57degreeC and the monohydrate at 65degreeC.
Chemical ID: MESH:C020748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb2multiple interactionsISOERBB2 (Homo sapiens)6480464CTDferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; ferrous sulfate inhibits the reaction [Quercetin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]PMID:18655187
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