GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Erbb2 | affects response to substance | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | ERBB2 protein affects the susceptibility to Paclitaxel | PMID:10327070 | Erbb2 | decreases response to substance | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | ERBB2 protein results in decreased susceptibility to Paclitaxel; ERBB2 results in decreased susceptibility to Paclitaxel | PMID:21712253 PMID:25866362 | Erbb2 | multiple interactions | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Paclitaxel]; 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Paclitaxel]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Paclitaxel; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Paclitaxel results in decreased phosphorylation of and results in decreased activity of ERBB2 protein | PMID:16580691 PMID:21712253 PMID:25866362 | | ||||||||||||||||||||||
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