Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2561
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb2decreases response to substanceISOERBB2 (Homo sapiens)6480464CTDERBB2 protein results in decreased susceptibility to TamoxifenPMID:15665275 PMID:16000581 PMID:16023854 PMID:19075277
Erbb2increases expressionISOErbb2 (Mus musculus)6480464CTDTamoxifen results in increased expression of ERBB2 proteinPMID:21138602
Erbb2increases phosphorylationISOErbb2 (Mus musculus)6480464CTDTamoxifen results in increased phosphorylation of ERBB2 proteinPMID:21138602
Erbb2increases phosphorylationISOERBB2 (Homo sapiens)6480464CTDTamoxifen results in increased phosphorylation of ERBB2 proteinPMID:17157789
Erbb2multiple interactionsISOERBB2 (Homo sapiens)6480464CTD[ERBB2 protein results in increased activity of ESR1 protein] which results in decreased susceptibility to Tamoxifen; ERBB2 protein inhibits the reaction [PA2G4 protein results in increased susceptibility to Tamoxifen]PMID:20179226 PMID:20379846
Go Back to source page   Continue to Ontology report