GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Erbb2 | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of ERBB2 mRNA | PMID:11241755 | Erbb2 | affects expression | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | sodium arsenite affects the expression of ERBB2 protein | PMID:17384772 | Erbb2 | decreases expression | ISO | Erbb2 (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of ERBB2 mRNA | PMID:37682722 | Erbb2 | increases expression | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of ERBB2 mRNA | PMID:32599262 | Erbb2 | increases phosphorylation | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased phosphorylation of ERBB2 protein | PMID:20043101 PMID:30137596 PMID:32890875 | Erbb2 | multiple interactions | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of and affects the phosphorylation of ERBB2 protein; CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the phosphorylation of ERBB2 protein]; CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of ERBB2 protein]; EGF protein promotes the reaction [sodium arsenite results in increased phosphorylation of ERBB2 protein]; ERBB2 mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; ERBB2 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]; ERBB2 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; ERBB2 protein affects the reaction [sodium arsenite results in increased expression of CCND1 protein]; ERBB2 protein affects the reaction [sodium arsenite results in increased expression of HIF1A protein]; ERBB2 protein affects the reaction [sodium arsenite results in increased expression of PCNA protein]; ERBB2 protein affects the reaction [sodium arsenite results in increased expression of PTGS2 protein]; ERBB2 protein affects the reaction [sodium arsenite results in increased expression of VEGFA protein]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CXCL8 mRNA]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]; ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CXCL8 protein]; Genistein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the phosphorylation of ERBB2 protein]; Genistein affects the reaction [ERBB2 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]]; Genistein affects the reaction [ERBB2 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]]; Genistein inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]]; Genistein inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]]; Genistein inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]]; Genistein inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]]; Genistein inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]]; HSP90AA1 protein promotes the reaction [sodium arsenite results in increased phosphorylation of ERBB2 protein]; IL6 protein inhibits the reaction [sodium arsenite results in increased phosphorylation of ERBB2 protein]; Lithium Chloride inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CXCL8 mRNA]]; Lithium Chloride inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CXCL8 protein]]; LY 290042 inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CXCL8 mRNA]]; LY 290042 inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CXCL8 protein]]; NDRG1 protein inhibits the reaction [sodium arsenite results in increased phosphorylation of ERBB2 protein]; NRG1 protein promotes the reaction [sodium arsenite results in increased phosphorylation of ERBB2 protein]; pyrazolanthrone inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CXCL8 mRNA]]; pyrazolanthrone inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CXCL8 protein]]; reparixin affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the phosphorylation of ERBB2 protein]; SB 203580 inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CXCL8 mRNA]]; SB 203580 inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CXCL8 protein]]; sodium arsenite results in increased phosphorylation of and results in increased activity of ERBB2 protein; TGFA protein promotes the reaction [sodium arsenite results in increased phosphorylation of ERBB2 protein]; tyrphostin AG825 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of ERBB2 protein]; U 0126 inhibits the reaction [ERBB2 protein affects the reaction [sodium arsenite results in increased expression of CCND1 protein]]; U 0126 inhibits the reaction [ERBB2 protein affects the reaction [sodium arsenite results in increased expression of PCNA protein]]; U 0126 inhibits the reaction [ERBB2 protein affects the reaction [sodium arsenite results in increased expression of PTGS2 protein]]; U 0126 inhibits the reaction [ERBB2 protein affects the reaction [sodium arsenite results in increased expression of VEGFA protein]]; U 0126 inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CXCL8 mRNA]]; U 0126 inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CXCL8 protein]] | PMID:15734884 PMID:30137596 PMID:32890875 PMID:33396024 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |