GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Erbb2 | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of ERBB2 protein | PMID:17308081 | Erbb2 | multiple interactions | EXP | | 6480464 | CTD | Doxorubicin promotes the reaction [HSP90AA1 protein binds to ERBB2 protein]; ERBB2 protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNI3 protein]]; ERBB2 protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]] | PMID:17308081 PMID:19801490 | Erbb2 | affects expression | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | Doxorubicin affects the expression of ERBB2 mRNA | PMID:15205334 | Erbb2 | affects response to substance | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | ERBB2 protein affects the susceptibility to Doxorubicin | PMID:10327070 | Erbb2 | decreases response to substance | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | ERBB2 protein results in decreased susceptibility to Doxorubicin; ERBB2 results in decreased susceptibility to Doxorubicin | PMID:21712253 PMID:25467193 PMID:25866362 | Erbb2 | increases expression | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of ERBB2 mRNA | PMID:29803840 | Erbb2 | multiple interactions | ISO | Erbb2 (Mus musculus) | 6480464 | CTD | NRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of ERBB2 protein] | PMID:15833803 | Erbb2 | multiple interactions | ISO | ERBB2 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Doxorubicin]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Doxorubicin]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Doxorubicin; [TOP2A protein co-treated with ERBB2 protein] results in increased susceptibility to Doxorubicin; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; ERBB2 affects the susceptibility to [Doxorubicin co-treated with Cyclophosphamide co-treated with docetaxel]; ERBB2 protein affects the susceptibility to [Cyclophosphamide co-treated with Doxorubicin co-treated with docetaxel]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]; ERBB2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]; NFE2L2 protein affects the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin] | PMID:15486187 PMID:15834928 PMID:16168102 PMID:17010609 PMID:21712253 PMID:25467193 PMID:25866362 PMID:9816327 | | ||||||||||||||||||||||
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