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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrmultiple interactionsEXP 6480464CTD[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of EGFR protein; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of EGFR protein]; Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; Methylnitrosourea results in increased phosphorylation of and results in decreased expression of EGFR protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of EGFR protein]PMID:22245120 PMID:25164625
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