GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egfr | affects response to substance | ISO | EGFR (Homo sapiens) | 6480464 | CTD | EGFR protein affects the susceptibility to lapatinib | PMID:28739874 | Egfr | decreases activity | ISO | EGFR (Homo sapiens) | 6480464 | CTD | lapatinib results in decreased activity of EGFR protein | PMID:15665275 PMID:17192538 PMID:19509167 PMID:20549698 | Egfr | multiple interactions | ISO | EGFR (Homo sapiens) | 6480464 | CTD | KRAS protein affects the reaction [EGFR protein affects the susceptibility to lapatinib]; lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]; lapatinib inhibits the reaction [EGFR protein binds to PTPN3 protein]; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]]; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to PTPN3 protein]] | PMID:28739874 | | ||||||||||||||||||||||
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