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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:4948
Term: Evodiamine
Definition: A beta-carboline that has formula C19H17N3O.
Chemical ID: MESH:C049639
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrincreases phosphorylationISOEgfr (Mus musculus)6480464CTDevodiamine results in increased phosphorylation of EGFR proteinPMID:19854188
Egfrmultiple interactionsISOEgfr (Mus musculus)6480464CTDEGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PLCG1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of EGFR protein]PMID:19854188
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