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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrdecreases expressionISOEGFR (Homo sapiens)6480464CTDPaclitaxel results in decreased expression of EGFR mRNAPMID:18058816
Egfrincreases phosphorylationISOEGFR (Homo sapiens)6480464CTDPaclitaxel results in increased phosphorylation of EGFR proteinPMID:16211241 PMID:20726858
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTD[PD168393 co-treated with Paclitaxel] results in decreased phosphorylation of EGFR protein; Paclitaxel promotes the reaction [HER3 protein binds to EGFR protein]PMID:16413505 PMID:20726858
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