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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2536
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ednrb
Name: endothelin receptor type B
Acc ID: CHEBI:10037
Term: wedelolactone
Definition: A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.
Chemical ID: MESH:C051122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ednrbmultiple interactionsEXP 6480464CTDwedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [Smoke results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB protein]PMID:18718921 PMID:20561571 PMID:22207076
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