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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1affects expressionISOEDN1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of EDN1 mRNAPMID:21632981
Edn1decreases expressionISOEdn1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of EDN1 mRNAPMID:21569818
Edn1decreases expressionISOEDN1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of EDN1 mRNAPMID:20106945 PMID:31255691
Edn1increases expressionISOEDN1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of EDN1 mRNAPMID:16269432 PMID:21871943 PMID:22316170 PMID:26238291
Edn1multiple interactionsISOEdn1 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to EDN1 promoter]PMID:19654925
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