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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of EDN1 proteinPMID:9357851
Edn1multiple interactionsEXP 6480464CTDCAT protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of EDN1 protein]PMID:9357851
Edn1affects expressionISOEDN1 (Homo sapiens)6480464CTDHydrogen Peroxide affects the expression of EDN1 mRNAPMID:20044591 PMID:23410634
Edn1increases expressionISOEDN1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of EDN1 mRNA; Hydrogen Peroxide results in increased expression of EDN1 proteinPMID:11755377 PMID:12414654 PMID:14623829 PMID:18234130 PMID:20021702
Edn1increases secretionISOEDN1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased secretion of EDN1 proteinPMID:14623829 PMID:20021702
Edn1multiple interactionsISOEDN1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]; epigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]; resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]; resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]; resveratrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]PMID:11755377 PMID:14623829 PMID:18234130 PMID:20021702
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