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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:7735
Term: olanzapine
Definition: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Chemical ID: MESH:C076029
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2multiple interactionsEXP 6480464CTDolanzapine promotes the reaction [Dopamine binds to DRD2 protein]PMID:15716360
Drd2affects activityISODRD2 (Homo sapiens)6480464CTDolanzapine affects the activity of DRD2 proteinPMID:10482380
Drd2affects bindingISODrd2 (Mus musculus)6480464CTDolanzapine binds to DRD2 proteinPMID:24389121
Drd2affects bindingISODRD2 (Homo sapiens)6480464CTDolanzapine binds to DRD2 proteinPMID:10831489 PMID:20361897
Drd2decreases activityISODRD2 (Homo sapiens)6480464CTDolanzapine results in decreased activity of DRD2 proteinPMID:11198054
Drd2increases response to substanceISODRD2 (Homo sapiens)6480464CTDDRD2 gene SNP results in increased susceptibility to olanzapine; DRD2 intron SNP results in increased susceptibility to olanzapinePMID:20375926 PMID:21187413
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