GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:5613
Term: haloperidol
Definition: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4; and an N-linked p-fluorobutyrophenone moiety.
CasRN: 52-86-8
Chemical ID: MESH:D006220
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDHaloperidol binds to DRD2 protein

PMID:12191584
PMID:9109525
multiple interactionsEXP 6480464CTDzinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein]

PMID:9109525
affects bindingISORGD:7367966480464CTDDRD2 protein binds to Haloperidol

DRD2 protein binds to Haloperidol analog

PMID:14552778
affects bindingISORGD:7367966480464CTDHaloperidol binds to DRD2 protein

PMID:20361897
PMID:11997696
increases expressionISORGD:7367966480464CTDHaloperidol results in increased expression of DRD2 mRNA

Haloperidol results in increased expression of DRD2 protein

PMID:20730801
multiple interactionsISORGD:7367966480464CTDThioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]

Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]

PMID:20730801
affects response to substanceISORGD:104866480464CTDDRD2 affects the susceptibility to Haloperidol

PMID:10720636
affects response to substanceISORGD:104866480464CTDDRD2 protein affects the susceptibility to Haloperidol

PMID:11172060
multiple interactionsISORGD:104866480464CTDHaloperidol binds to and results in decreased activity of DRD2 protein

[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Ethanol

PMID:19120057
affects bindingISORGD:104866480464CTDHaloperidol binds to DRD2

PMID:8794996
affects bindingISORGD:104866480464CTDHaloperidol binds to DRD2 protein alternative form

PMID:12476322
increases expressionISORGD:104866480464CTDHaloperidol results in increased expression of DRD2 protein

PMID:2945998
affects bindingISORGD:104866480464CTDHaloperidol binds to DRD2 protein

PMID:9808703
multiple interactionsISORGD:104866480464CTD[Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital

PMID:2945998
multiple interactionsEXP 6480464CTDDRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]

DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]

DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]

DRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]

PMID:16144542
multiple interactionsEXP 6480464CTDcyclo(leucylglycine) inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]

PMID:8115415
multiple interactionsEXP 6480464CTDHaloperidol binds to and results in decreased activity of DRD2 protein

[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein

PMID:16033416
affects bindingEXP 6480464CTDHaloperidol binds to DRD2 protein

PMID:12191584
multiple interactionsEXP 6480464CTDfelbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein]

PMID:7845605
multiple interactionsEXP 6480464CTDHaloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]

PMID:10936494
multiple interactionsEXP 6480464CTDHaloperidol inhibits the reaction [Spiperone binds to DRD2 protein]

PMID:11927170
multiple interactionsEXP 6480464CTDHaloperidol promotes the reaction [Dopamine binds to DRD2 protein]

PMID:15716360
increases expressionEXP 6480464CTDHaloperidol results in increased expression of DRD2

PMID:1351265
increases expressionEXP 6480464CTDHaloperidol results in increased expression of DRD2 protein

PMID:8115415
PMID:8200438
PMID:18295747
affects bindingISORGD:7367966480464CTDHaloperidol binds to DRD2 protein

PMID:11997696
PMID:20361897
increases expressionEXP 6480464CTDHaloperidol results in increased expression of DRD2 protein

PMID:18295747
PMID:8200438
PMID:8115415
multiple interactionsEXP 6480464CTDHaloperidol inhibits the reaction [iodosulpride binds to DRD2 protein]

PMID:7878047
increases expressionEXP 6480464CTDHaloperidol results in increased expression of DRD2 protein

PMID:18295747
PMID:8115415
PMID:8200438
increases expressionEXP 6480464CTDHaloperidol results in increased expression of DRD2 mRNA

PMID:7878047
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