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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2518
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd1
Name: dopamine receptor D1
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd1affects bindingEXP 6480464CTDClozapine binds to DRD1 proteinPMID:9723970
Drd1affects bindingISODrd1 (Mus musculus)6480464CTDClozapine analog binds to DRD1 proteinPMID:11997696
Drd1affects bindingISODRD1 (Homo sapiens)6480464CTDClozapine binds to DRD1 proteinPMID:11997696 PMID:1352677
Drd1affects response to substanceISODRD1 (Homo sapiens)6480464CTDDRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to ClozapinePMID:17092969
Drd1decreases expressionISODrd1 (Mus musculus)6480464CTDClozapine results in decreased expression of DRD1 mRNAPMID:17266109
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