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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503 Species: Rattus norvegicus RGD Object: Gene Symbol: Nqo1 Name: NAD(P)H dehydrogenase, quinone 1

Acc ID: CHEBI:35170 Term: vanadium(0) Definition: An elemental vanadium that has formula V. CasRN: 7440-62-2 Chemical ID: MESH:D014639

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:10473	6480464	CTD	Vanadium results in decreased expression of NQO1 mRNA	PMID:19367690
multiple interactions	ISO	RGD:10473	6480464	CTD	Vanadium inhibits the reaction [sulforafan affects the localization of NQO1 protein] Vanadium inhibits the reaction [sulforafan results in increased activity of NQO1 protein] Vanadium inhibits the reaction [sulforafan results in increased expression of NQO1 mRNA] Vanadium inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NQO1 protein] Vanadium inhibits the reaction [sulforafan results in increased expression of NQO1 protein] Vanadium inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein] Vanadium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 protein] Vanadium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]	PMID:19367690
increases stability	ISO	RGD:10473	6480464	CTD	Vanadium results in increased stability of NQO1 protein	PMID:19367690