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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503 Species: Rattus norvegicus RGD Object: Gene Symbol: Nqo1 Name: NAD(P)H dehydrogenase, quinone 1

Acc ID: CHEBI:34718 Term: 1-chloro-2,4-dinitrobenzene Definition: A chlorobenzene compound with two nitro substituents in the 2- and 4-positions. CasRN: 97-00-7 Chemical ID: MESH:D004137

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:735868	6480464	CTD	Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of NQO1 mRNA]	PMID:19033392
increases expression	ISO	RGD:735868	6480464	CTD	Dinitrochlorobenzene results in increased expression of NQO1 mRNA	PMID:16314067 PMID:20566472 PMID:19033392
increases expression	ISO	RGD:735868	6480464	CTD	Dinitrochlorobenzene results in increased expression of NQO1 mRNA	PMID:16314067 PMID:19033392 PMID:20566472
increases expression	ISO	RGD:735868	6480464	CTD	Dinitrochlorobenzene results in increased expression of NQO1 mRNA	PMID:20566472 PMID:16314067 PMID:20491607 PMID:19033392
increases expression	ISO	RGD:735868	6480464	CTD	Dinitrochlorobenzene results in increased expression of NQO1 mRNA	PMID:19033392 PMID:16314067 PMID:20566472 PMID:20491607
increases expression	ISO	RGD:735868	6480464	CTD	Dinitrochlorobenzene results in increased expression of NQO1 mRNA	PMID:16314067 PMID:19033392 PMID:20491607 PMID:20566472
increases expression	ISO	RGD:735868	6480464	CTD	Dinitrochlorobenzene results in increased expression of NQO1 mRNA	PMID:16314067 PMID:19033392 PMID:20146380 PMID:20491607 PMID:20566472