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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2493 Species: Rattus norvegicus RGD Object: Gene Symbol: Ace Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Acc ID: CHEBI:9241 Term: spironolactone Definition: A steroid lactone that has formula C24H32O4S. CasRN: 52-01-7 Chemical ID: MESH:D013148

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein] Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]	PMID:15932931
decreases expression	EXP		6480464	CTD	Spironolactone results in decreased expression of ACE protein	PMID:18586661