Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:82358
Term: N-Nitrosodi-n-propylamine
Definition: A nitroso compound that has formula C6H14N2O.
Chemical ID: MESH:C013161
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1affects metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein affects the metabolism of N-nitroso(di-n-propyl)aminePMID:10910959
Cyp2e1increases activityISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased activity of N-nitroso(di-n-propyl)aminePMID:15728263
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTD[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to N-nitroso(di-n-propyl)amine; [CYP2E1 protein co-treated with POR protein] results in increased susceptibility to N-nitroso(di-n-propyl)amine; CYB5A protein promotes the reaction [CYP2E1 protein results in increased activity of N-nitroso(di-n-propyl)amine]PMID:11035158 PMID:11733072 PMID:15728263
Go Back to source page   Continue to Ontology report